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A novel DMSO-assisted regioselective iodination of aniline analogues
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2020-09-14 , DOI: 10.1016/j.tetlet.2020.152461
Pakorn Bovonsombat , Wanutcha Lorpaiboon , Sarocha Laoboonchai , Prima Sriprachaya-anunt , Warangkana Yimkosol , Natthapatch Siriphatcharachaikul , Pornpawit Siricharoensang , Terawee Kangwannarakul , Jin Maeda , Satreerat Losuwanakul , Maitraye Mahesh Abhyankar

A metal- and oxidant-free electrophilic iodination of aniline analogues was achieved in high to excellent yields at room temperature in MTBE with 0 or 3.5 equivalents of DMSO. Examined substituents include N-alkyl, N,N-dialkyl, N-morpholinyl and N-piperazinyl as well as methyl, Br, CN and CO2CH3 aryl ring substitutions.



中文翻译:

新型DMSO辅助的苯胺类似物的区域选择性碘化

在室温下,使用0或3.5当量的DMSO,在MTBE中以高至优异的产率实现了苯胺类似物的无金属和无氧化剂亲电碘化。检查的取代基包括N-烷基,NN-二烷基,N-吗啉基和N-哌嗪基以及甲基,Br,CN和CO 2 CH 3芳基环取代。

更新日期:2020-10-12
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