The study investigates the effects of 6 occlusion conditions on the mechanically induced cough reflex in 15 anesthetized (pentobarbital) spontaneously breathing cats (14♂, 1♀). Esophageal pressure and integrated EMG activities of inspiratory (I) diaphragm and expiratory (E) abdominal muscles were recorded and analyzed.

Occlusions: inspiratory (Io), continual I (cIo), during I and active E (I+Eo) cough phase, during I and then E phase with short releasing of airflow before each phase (I-Eo), and E occlusion (Eo) had little influence on cough number. Only continual E occlusion (cEo) reduced the number of coughs by 19 % (to 81 %, p < 0.05). Cough I esophageal pressure reached higher amplitudes under all conditions, but only Eo caused increased I diaphragm motor drive (p < 0.05). Cough E efforts (abdominal motor drive and E amplitudes of esophageal pressure) increased during Eo, decreased during I+Eo (p < 0.05), and did not change significantly under other conditions (p > 0.05). All I blocks resulted in prolonged I cough characteristics (p < 0.05) mainly cough I phase (incrementing part of the diaphragm activity). Shorter I phase occurred with cEo (p < 0.05). Cough cycle time and active E phase (from the I maximum to the end of cough E motor drive) prolonged (p < 0.05) during all occlusions (E phase duration statistically non-significantly for I+Eo).

Airflow block during cough (occlusions) results in secondary changes in the cough response due to markedly altered function of cough central pattern generator and cough motor pattern produced. Cough compensatory effects during airflow resistances are more favorable compared to occlusions. Volume feedback represents significant factor of cough modulation under various pathological obstruction and/or restriction conditions of the respiratory system.

该研究调查了 6 种闭塞条件对 15 只麻醉（戊巴比妥）自主呼吸猫（14♂，1♀）的机械诱导咳嗽反射的影响。记录和分析吸气 (I) 膈肌和呼气 (E) 腹肌的食管压力和综合 EMG 活动。

闭塞：吸气 (Io)、持续 I (cIo)、I 和主动 E (I+Eo) 咳嗽阶段、I 和 E 阶段，在每个阶段之前短暂释放气流 (I-Eo)，以及 E 闭塞 ( Eo)对咳嗽次数影响不大。只有持续的 E 闭塞 (cEo) 才能将咳嗽次数减少 19%（至 81%，p < 0.05）。咳嗽 I 食管压力在所有条件下都达到更高的幅度，但只有 Eo 导致 I 隔膜电机驱动增加（p < 0.05）。咳嗽 E 努力（腹部运动驱动和 E 食管压力振幅）在 Eo 期间增加，在 I+Eo 期间减少（p < 0.05），并且在其他条件下没有显着变化（p > 0.05）。所有 I 阻滞导致延长的 I 咳嗽特征（p < 0.05），主要是咳嗽 I 期（增加部分膈肌活动）。cEo 出现较短的 I 期（p < 0.05）。在所有闭塞期间，咳嗽周期时间和活动 E 阶段（从 I 最大值到咳嗽 E 运动驱动结束）延长（p < 0.05）（对于 I+Eo，E 阶段持续时间在统计上不显着）。

由于咳嗽中枢模式发生器和咳嗽运动模式产生的功能显着改变，咳嗽期间气流阻塞（阻塞）导致咳嗽反应的继发性变化。与阻塞相比，气流阻力期间的咳嗽代偿效果更有利。在呼吸系统的各种病理性阻塞和/或限制条件下，体积反馈代表咳嗽调节的重要因素。