Objective

To identify the types of adverse drug events (ADEs) that drug-drug interaction (DDI) alerts are trying to prevent in hospitalized patients.

Methods

This was a retrospective cross-sectional study conducted in a tertiary referral hospital in Australia. All DDI alerts encountered by prescribers during a 1-month period were evaluated for potential ADEs targeted for prevention. If the same DDI alert occurred for the same patient multiple times during hospitalization, it was counted only once (i.e. first alert). This was termed a ‘unique DDI alert’ for a given patient. The primary outcome was the type of ADE the alerts were trying to prevent.

Results

There were 715 patients who had 1599 unique DDI alerts. The two most common potential ADEs (not mutually exclusive) that the alerts attempted to prevent were QTc prolongation or torsades de pointes (n = 1028/1599, 64 %), followed by extrapyramidal symptoms or neuroleptic malignant syndrome (n = 463/1599, 29 %). Either of these two potential ADEs were present in 83 % (n = 1329/1599) of unique DDI alerts.

Conclusion

Alerting systems are primarily trying to prevent two types of potential ADEs, which were included in more than 80 % of DDI alerts. This has important implications for patient monitoring in hospitals.

中文翻译：

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药物相互作用引起的不良事件提醒住院患者。

目的

为了确定药物相互作用（DDI）警报试图在住院患者中预防的不良药物事件（ADE）的类型。

方法

这是在澳大利亚一家三级转诊医院进行的回顾性横断面研究。对处方者在1个月内遇到的所有DDI警报进行了评估，以预防潜在的ADE。如果同一患者在住院期间多次发生相同的DDI警报，则仅计数一次（即第一次警报）。这被称为给定患者的“唯一DDI警报”。主要结果是警报试图阻止的ADE类型。

结果

有715名患者具有1599个独特的DDI警报。警报试图阻止的两种最常见的潜在ADEs（并非互斥）是QTc延长或尖峰扭转（n = 1028 / 1599，64％），其次是锥体束外症状或神经安定性恶性综合征（n = 463/1599， 29％）。这两种潜在的ADE均以83％（n = 1329/1599）的唯一DDI警报形式出现。

结论

警报系统主要试图防止两种类型的潜在ADE，它们被包含在80％以上的DDI警报中。这对医院的患者监测具有重要意义。