Photosensitizers (PSs) are chemical entities that upon light exposure are able to produce cytotoxic species such as singlet oxygen superoxide and free radicals. PSs are used in photodynamic therapy applications (PDT) to eradicate cancer cells, pathogenic bacteria, fungi, and viruses. Development of the NIR-activatable photosensitizes with high phototoxicity and low toxicity in dark conditions is challenging. Here we first report on the synthesis and antimicrobial testing of the new NIR photosensitizers based on the iodinated xanthene-cyanine dyes. These new photosensitizers exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration (~0.5 μM) and low NIR light dose (24.3 J/cm²).

光敏剂（PSs）是化学实体，在曝光后能够产生细胞毒性物质，例如单线态氧超氧化物和自由基。PS用于光动力疗法应用（PDT）中以根除癌细胞，病原细菌，真菌和病毒。在黑暗条件下开发具有高光毒性和低毒性的可NIR活化的光敏剂具有挑战性。在这里，我们首先报道基于碘化x吨-花青染料的新型NIR光敏剂的合成和抗菌测试。这些新的光敏剂在低染料浓度（〜0.5μM）和低NIR光剂量（24.3 J / cm ²）下对金黄色葡萄球菌病原体表现出很高的抗菌功效。