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Changes in mercury distribution and its body burden in delphinids affected by a morbillivirus infection: Evidences of methylmercury intoxication in Guiana dolphin
Chemosphere ( IF 8.8 ) Pub Date : 2020-09-13 , DOI: 10.1016/j.chemosphere.2020.128286
B.M.R. Manhães , E.B. Santos-Neto , L.R. Tovar , E.B. Guari , L. Flach , D. Kasper , P.M.A. Galvão , O. Malm , R.A. Gonçalves , T.L. Bisi , A.F. Azevedo , J. Lailson-Brito

An unusual mortality event (UME) attributed to morbillivirus infection was identified in two Guiana dolphin populations from the Southeastern Brazilian coast. The aim of this study was to characterize total mercury (THg), methylmercury (MeHg) and selenium (Se) bioaccumulation and body burden in Guiana dolphins from Sepetiba Bay (RJ) collected before (n=61) and during the UME (n=20). Significantly lower Se concentrations were found in the livesr of individuals collected during the UME (Mann-Whitney test; p= 0,03), probably due to impairment of the detoxification process in the liver. There were differences in THg and Se concentrations in the organs and tissues of individuals (Kruskal-Wallis test, p <0.05), but not MeHg (Kruskal-Wallis test, p=0.07). For THg, the liver showed the higher concentrations and differed among organs and tissues analyzed such as blubber (Tukey’s test for unequal N; p=0.003). For Se concentrations, the skin and kidney presented the higher concentrations and varied among other tissues/organs, like muscle (Tukey’s test for unequal N; p = 0.02). Differences in body burdens were observed among specimens collected previously and during the UME probably due to the remobilization and transport of the muscle-stored MeHg to other tissues/organs. This abrupt input of MeHg into the bloodstream may cause serious health damage. Indeed, evidences of methylmercury intoxication was observed in Guiana dolphins in Sepetiba Bay. In conclusion, bioaccumulation patterns, the detoxification process and body burden were affected by morbillivirus.



中文翻译:

感染脊髓灰质炎病毒的翠雀中汞分布及其人体负担的变化:圭亚那海豚中甲基汞中毒的证据

在巴西东南沿海的两个圭亚那海豚种群中发现了一种异常病毒,该病毒归因于脊髓灰质炎病毒感染。这项研究的目的是表征在西非美a湾(RJ)之前(n = 61)和在UME(n =)收集的圭亚那海豚中的总汞(THg),甲基汞(MeHg)和硒(Se)的生物累积和人体负荷。 20)。在UME(曼恩-惠特尼检验; p = 0.03)期间收集的个体的肝脏中发现硒浓度明显降低,这可能是由于肝脏排毒过程受到损害所致。个体器官和组织中的THg和Se浓度存在差异(Kruskal-Wallis检验,p <0.05),而MeHg没有差异(Kruskal-Wallis检验,p = 0.07)。对于THg,肝脏显示出较高的浓度,并且在所分析的器官和组织(如脂肪)中有所不同(Tukey's test for N等分; p = 0.003)。对于硒浓度,皮肤和肾脏中的硒含量较高,并且在其他组织/器官(如肌肉)中也有所不同(Tukey's检验不等N; p = 0.02)。在先前和在UME期间收集的标本之间观察到身体负担的差异,可能是由于肌肉存储的MeHg的移动和向其他组织/器官的运输。MeHg突然输入到血液中可能会严重损害健康。确实,在Sepetiba湾的圭亚那海豚中发现了甲基汞中毒的证据。总之,麻疹病毒会影响生物蓄积模式,排毒过程和身体负担。003)。对于硒浓度,皮肤和肾脏中的硒含量较高,并且在其他组织/器官(如肌肉)中也有所不同(Tukey's检验不等N; p = 0.02)。在先前和在UME期间收集的标本之间观察到身体负担的差异,可能是由于肌肉存储的MeHg的移动和向其他组织/器官的运输。MeHg突然输入到血液中可能会严重损害健康。确实,在Sepetiba湾的圭亚那海豚中发现了甲基汞中毒的证据。总之,麻疹病毒会影响生物累积模式,排毒过程和身体负担。003)。对于硒浓度,皮肤和肾脏中的硒含量较高,并且在其他组织/器官(如肌肉)中也有所不同(Tukey's检验不等N; p = 0.02)。在先前和在UME期间收集的标本之间观察到身体负担的差异,可能是由于肌肉存储的MeHg的移动和向其他组织/器官的运输。MeHg突然输入到血液中可能会严重损害健康。确实,在Sepetiba湾的圭亚那海豚中发现了甲基汞中毒的证据。总之,麻疹病毒会影响生物累积模式,排毒过程和身体负担。在先前和在UME期间收集的标本之间观察到身体负担的差异,可能是由于肌肉存储的MeHg的移动和向其他组织/器官的运输。MeHg突然输入到血液中可能会严重损害健康。确实,在Sepetiba湾的圭亚那海豚中发现了甲基汞中毒的证据。总之,麻疹病毒会影响生物蓄积模式,排毒过程和身体负担。在先前和在UME期间收集的标本之间观察到身体负担的差异,可能是由于肌肉存储的MeHg的移动和向其他组织/器官的运输。MeHg突然输入到血液中可能会严重损害健康。确实,在Sepetiba湾的圭亚那海豚中发现了甲基汞中毒的证据。总之,麻疹病毒会影响生物蓄积模式,排毒过程和身体负担。

更新日期:2020-09-14
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