Nanoscale metal coordination polymers (NCPs), built from metal ions and organic ligands, have attracted tremendous interest in biomedical applications. This is mainly due to their mesoporous structure, tunable size and morphology and versatile functionality. NCPs can be further divided into nanoscale metal-organic frameworks (NMOFs) and amorphous coordination polymer particles (ACPPs) depending on their structural crystallinity. NMOFs as nanocarriers have been extensively reviewed. However, the highlights of ACPPs as theranostic nanoplatforms are still limited. In this review, the recent progress of ACPPs as theranostic nanoplatforms is summarized based on what types of organic linkers used. The ACPPs are divided into three main parts: photosensitizers-based ACPPs, chemical drugs-based ACPPs, and biomolecules-based ACPPs. Finally, the prospects and challenges of the ACPPs for enhanced biomedical applications are also discussed.

Statement of Significance

Over the last decades, amorphous metal coordination polymers (ACPPs), constructed by metal ions and organic linkers, have attracted enormous interest in cancer treatment owing to their high drug loading capability, facile synthetic procedures, low long-term toxicity, and mild preparation conditions. In this review, we highlight the recent progress of ACPPs for biomedical application based on different types of organic building blocks including photosensitizers, chemical drugs, and biomolecules. Moreover, the prospects and challenges of ACPPs for clinical application are also discussed. We hope this review entitled “Recent development of amorphous metal coordination polymers for cancer therapy” would arise the researchers’ interest in this field to accelerate their clinical application in cancer therapy.

中文翻译：

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用于癌症治疗的非晶态金属配位聚合物的最新进展。

由金属离子和有机配体构建的纳米级金属配位聚合物（NCP）在生物医学应用中引起了极大的兴趣。这主要是由于它们的介孔结构，可调整的大小和形态以及通用的功能。NCP可以根据其结构结晶度进一步分为纳米级金属-有机骨架（NMOF）和非晶态配位聚合物颗粒（ACPP）。NMOFs作为纳米载体已得到广泛的审查。但是，ACPPs作为治疗诊断性纳米平台的亮点仍然有限。在这篇综述中，基于使用的有机连接剂类型总结了ACPP作为治疗型纳米平台的最新进展。ACPP分为三个主要部分：基于光敏剂的ACPP，基于化学药物的ACPP和基于生物分子的ACPP。最后，

重要声明

在过去的几十年中，由金属离子和有机连接基构成的无定形金属配位聚合物（ACPPs）由于具有高载药量，合成方法简便，长期毒性低以及制备条件温和而引起了人们对癌症治疗的极大兴趣。 。在这篇综述中，我们重点介绍基于不同类型的有机构件（包括光敏剂，化学药物和生物分子）的生物医学应用ACPP的最新进展。此外，还讨论了ACPP在临床应用中的前景和挑战。我们希望这篇题为“非晶态金属配位聚合物在癌症治疗中的最新进展”的综述会引起研究人员对该领域的兴趣，以加速其在癌症治疗中的临床应用。