Abstract

A spectrometer based on silicon nanosandwiches (SNSs) is proposed for problems of personalized medicine. SNS structures exhibit properties of terahertz (THz) emitter and receiver of the THz response of biological tissue. Measurements of the I–V characteristics of the SNS structure make it possible to analyze the spectral composition of the THz response of biological tissue and determine relative contributions of various proteins and amino acids contained in the structure of DNA oligonucleotides and the corresponding compounds. Evident advantages of the proposed method are related to the fact that the THz response can be directly obtained from living biological tissue and, hence, used for express analysis of the DNA oligonucleotides. Tests of several control groups show that the further analysis of the specific features of the spectral peaks of the SNS I–V characteristics is of interest for methods of personalized diagnostics and treatment.

中文翻译：

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生物组织的太赫兹响应在个性化医学中的诊断和治疗

摘要

提出了一种基于硅纳米三明治（SNSs）的光谱仪，用于个性化医学问题。SNS结构具有太赫兹（THz）发射器和生物组织的THz响应接收器的特性。I – V的测量SNS结构的特征使得可以分析生物组织的THz响应的光谱组成，并确定DNA寡核苷酸和相应化合物的结构中包含的各种蛋白质和氨基酸的相对贡献。所提出的方法的明显优势与以下事实有关：可以从活的生物组织直接获得THz响应，因此可用于DNA寡核苷酸的表达分析。对几个对照组的测试表明，对于个性化诊断和治疗方法而言，对SNS I – V特性谱峰的特定特征进行进一步分析是很有意义的。