Abstract

Synthetic hydroxyapatite nanoparticles that contain ammonium chloride crystals are obtained. The X-ray diffraction, thermogravimetric analysis, and BET methods show that ammonium chloride crystals are decomposed in argon in the temperature range of T = 220–270°C. The heat treatment at T = 300°C gives thermal stability to the nanoparticles. The presence of ammonium chloride in the culture medium has a substantial effect on the biocompatibility of nanoparticles. An increase in its content reduces the proliferative activity of mesenchymal stromal cells.

中文翻译：

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氯化铵对羟基磷灰石纳米颗粒结构和间质基质细胞增殖活性的影响

摘要

获得了包含氯化铵晶体的合成羟基磷灰石纳米颗粒。X射线衍射，热重分析和BET方法表明，在T = 220–270°C的温度范围内，氯化铵晶体在氩气中分解。在T＝ 300℃下的热处理使纳米颗粒具有热稳定性。培养基中氯化铵的存在对纳米颗粒的生物相容性具有实质性影响。其含量的增加降低了间充质基质细胞的增殖活性。