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Non-medical applications of tissue engineering: biofabrication of a leather-like material
Materials Today Sustainability ( IF 7.8 ) Pub Date : 2019-05-24 , DOI: 10.1016/j.mtsust.2019.100018
K. Jakab , F. Marga , R. Kaesser , T.-H. Chuang , H. Varadaraju , D. Cassingham , S. Lee , A. Forgacs , G. Forgacs

Most tissue engineering efforts are focused on applications in regenerative medicine to improve the quality of life of patients. Despite spectacular progress in the last 20 years, the expected breakthrough to replace dysfunctional tissues in the organism or mitigate the chronic shortage of donor organs has not yet been achieved. This is not surprising, given the enormous challenge facing the biofabrication of complex living structures in vitro and the associated astronomical expenditures. Here, we propose a more modest but more realistic utilization of the knowledge accumulated in tissue engineering and associated biofabrication technologies over the years. We describe specific efforts to engineer the particular compartment of a complex tissue, the skin that gives rise to a commercially useful leather-like material. We take the reader through the entire process from the sourcing of collagen-secreting cells, to the engineering, tanning and final finishing of the material. We analyze the composition, structure, and physical properties of the final product. We compare our process with that followed by the leather industry to point out the advantages and disadvantages of both.



中文翻译:

组织工程的非医学应用:类皮革材料的生物制造

大多数组织工程工作都集中在再生医学中,以改善患者的生活质量。尽管在过去20年中取得了令人瞩目的进步,但尚未实现替代机体功能障碍组织或减轻供体器官长期短缺的预期突破。考虑到体外复杂生物结构生物制造面临的巨大挑战以及相关的天文支出,这不足为奇。在这里,我们提出对组织工程和相关生物制造技术多年来积累的知识的更适度但更实际的利用。我们描述了对复杂组织的特定部分进行改造的具体工作,这些复杂部分会产生商业上有用的皮革状材料。我们将引导读者完成从分泌胶原蛋白的细胞到材料的工程,鞣制和最终整理的整个过程。我们分析最终产品的组成,结构和物理性质。我们将我们的流程与皮革行业的流程进行比较,以指出两者的优缺点。

更新日期:2019-05-24
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