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Investigations on isolated peptides by combined IR/UV spectroscopy in a molecular beam – structure, aggregation, solvation and molecular recognition
International Reviews in Physical Chemistry ( IF 6.1 ) Pub Date : 2016-10-01 , DOI: 10.1080/0144235x.2016.1229331
Kirsten Schwing , Markus Gerhards

The well-known correlation between structure and functionality has motivated generations of scientists to intensively investigate the structural behaviour of peptide and protein systems, e.g. their folding, their aggregation reactions or the process of molecular recognition. A variety of environmental effects on peptide structures occur among them the influence of solvent molecules or aggregation partners; a further decisive factor is the amino acid sequence. Thus a bottom-up approach comprises the investigation of isolated peptide systems, increasing in size, as well as a successive introduction of potential aggregation partners. For this purpose mass and isomer selective combined IR/UV investigations in a molecular expansion represent ideal experiments to analyse intrinsic structural properties of peptides and aggregates. Against this background the presented review article illustrates general aspects of peptide structure, spectroscopic methods and experimental set-ups in the first part. This overview is followed by a summary of the current results in this field of research including a more detailed discussion of our work but also selected findings of other groups.

中文翻译:

通过分子束中的组合红外/紫外光谱研究分离的肽——结构、聚集、溶剂化和分子识别

结构和功能之间众所周知的相关性促使几代科学家深入研究肽和蛋白质系统的结构行为,例如它们的折叠、聚集反应或分子识别过程。各种环境对肽结构的影响发生在其中,溶剂分子或聚集体的影响;另一个决定性因素是氨基酸序列。因此,自下而上的方法包括研究分离的肽系统,增加大小,以及连续引入潜在的聚集伙伴。为此,分子扩展中的质量和异构体选择性组合 IR/UV 研究代表了分析肽和聚集体的内在结构特性的理想实验。在此背景下,本综述文章在第一部分阐述了肽结构、光谱方法和实验装置的一般方面。此概述之后是对该研究领域当前结果的总结,包括对我们工作的更详细讨论,以及其他小组的精选发现。
更新日期:2016-10-01
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