Abstract Nanofibrous scaffold holds a great potential in remodeling of the damaged tissue. This work attempts to fabricate a fibrous wound dressing scaffold based on polyurethane (PU) mats reinforced with turmeric oil via electrospinning technique. The field emission electron microscopy (FESEM) depicted the smaller fiber diameter of nanocomposites compared to polyurethane. Fourier transform infrared spectroscopy (FTIR) and thermal analyses insinuated the existence of turmeric in the PU matrix by the formation of hydrogen bond and reduced weight loss for composite scaffold. Contact angle of the PU scaffold showed a hydrophobic behavior while turmeric oil incorporation resulted in the hydrophilic nature. Atomic force microscopy (AFM) analysis showed a decrease in surface roughness of PU with the addition of turmeric oil. In blood compatibility results, the coagulation times were observed to the higher for PU/turmeric oil than PU. The developed nanocomposites showed a less percentage of lysis of red blood cells suggesting better blood compatibility than PU. Further, cell viability assay depicted enhanced proliferation of fibroblast cells in the developed composites than PU. Overall, it was concluded that fabricated novel scaffold having better physicochemical and good biocompatibility characteristics for wound dressing.

中文翻译：

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用于伤口愈合应用的掺入姜黄油的定制纤维聚氨酯支架的物理化学评估

摘要 纳米纤维支架在损伤组织的重塑方面具有巨大的潜力。这项工作试图通过静电纺丝技术制造一种基于用姜黄油增强的聚氨酯 (PU) 垫的纤维伤口敷料支架。场发射电子显微镜 (FESEM) 显示与聚氨酯相比，纳米复合材料的纤维直径更小。傅里叶变换红外光谱 (FTIR) 和热分析通过形成氢键和减少复合支架的重量损失来暗示 PU 基质中存在姜黄。PU 支架的接触角显示出疏水性，而姜黄油的掺入导致亲水性。原子力显微镜 (AFM) 分析表明，加入姜黄油后 PU 的表面粗糙度降低。在血液相容性结果中，观察到 PU/姜黄油的凝固时间高于 PU。所开发的纳米复合材料显示出较低的红细胞裂解百分比，表明比 PU 具有更好的血液相容性。此外，细胞活力测定表明，与 PU 相比，所开发的复合材料中成纤维细胞的增殖增强。总的来说，可以得出结论，制造的新型支架具有更好的物理化学和良好的生物相容性特性，用于伤口敷料。