In response to a growing demand for more sustainable and cost-effective synthetic processes, the pharmaceutical industry is increasingly relying on continuous manufacturing as a valuable alternative to conventional batch processing. Particularly, flow processing may enable process intensification of chemocatalytic and biocatalytic transformations, both being of strategic importance on the design and production of active pharmaceutical ingredients. This review outlines the current status of flow chemocatalysis and biocatalysis within the pharmaceutical landscape. Furthermore, the trends and challenges that these technologies face are highlighted, based on recently disclosed applications from industry and innovative solutions from academia.

为响应对更可持续和更具成本效益的合成工艺的不断增长的需求，制药行业越来越依赖连续生产作为常规批处理的有价值的替代方法。特别地，流动处理可以使化学催化和生物催化转化的过程增强，这对于活性药物成分的设计和生产都具有战略重要性。这篇综述概述了药物领域内流式化学催化和生物催化的现状。此外，基于最近披露的行业应用和学术界的创新解决方案，这些技术面临的趋势和挑战得到了突出显示。