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Facile Synthesis of Isoniazid Derivatives – 1-[2-(3-Aryl(Hetaryl)-1-Phenyl-1 H -Pyrazol-4-yl)-5-(Pyridin-4-yl)-1,3,4-Oxadiazol-3(2 H )-yl]Ethanones
Chemistry of Heterocyclic Compounds ( IF 1.5 ) Pub Date : 2020-06-09 , DOI: 10.1007/s10593-020-02708-2
Faryal Chaudhry , Munawar Ali Munawar , Misbahul Ain Khan

A facile and efficient ultrasound-aided approach has afforded cyclization of isoniazid hydrazones into 2,5-bishetaryloxadiazolines at ambient temperature. Acetic anhydride helped in intramolecular oxidative cyclization along with N-acylation of oxadiazoline. The synthesized 1-[2-(1-phenyl-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethanones were isolated in good yields, spectral data supported the proposed structures.


中文翻译:

异烟肼衍生物的简便合成-1- [2-(3-芳基(杂芳基)-1-苯基-1H-吡唑-4-基)-5-(吡啶-4-基)-1,3,4-恶二唑-3(2 H)-基]乙酮

一种简便有效的超声辅助方法已使异烟肼hydr在环境温度下环化为2,5-二ishetaryloxadiazolines。乙酸酐与恶二唑啉的N-酰化反应一起有助于分子内氧化环化反应。合成的1- [2-(1-苯基-1 H-吡唑-4-基)-5-(吡啶-4-基)-1,3,4-恶二唑-3(2 H)-基]乙炔是如果以良好的产率分离,则光谱数据支持所提出的结构。
更新日期:2020-06-09
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