ABSTRACT The effect of grain size of hydroxyapatite on its osteoconductivity was newly investigated. The hydroxyapatite discs, which had small (specimen S) and large grain size (specimen L), were prepared through microwave sintering at 1100°C for 6 and 720 min, respectively. The average grain size of specimen S was about 15 times smaller than that of specimen L. The surface energy of specimen S was about 1.6 times higher than that of specimen L under the same surface roughness. For the osteoconductivity test, porous hydroxyapatite granules were prepared using PEG porogen. The osteoconductivity of specimen S was superior to that of specimen L four weeks after implantation in calvarial defects of New Zealand white rabbits. Taken together, it can be concluded that the hydroxyapatite with small grain size had a higher osteoconductivity compared with the hydroxyapatite with large grain size due to its high surface energy.

中文翻译：

---

小颗粒和大颗粒羟基磷灰石的体内评价

摘要 新研究了羟基磷灰石粒度对其骨传导性的影响。通过分别在 1100°C 和 6 分钟和 720 分钟的微波烧结制备具有小（试样 S）和大粒度（试样 L）的羟基磷灰石圆​​盘。试样S的平均晶粒尺寸比试样L小约15倍。在相同表面粗糙度下，试样S的表面能比试样L高约1.6倍。对于骨传导性测试，使用 PEG 致孔剂制备多孔羟基磷灰石颗粒。新西兰白兔颅骨缺损植入4周后，标本S的骨传导性优于标本L。综合起来，