Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion.,Acta Physiologica

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Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion.
Acta Physiologica ( IF 6.3 ) Pub Date : 2020-09-12 , DOI: 10.1111/apha.13558
Li Zhang _{1,

2} , Xi-Xi Zeng _{1,

2,

3} , Yu-Mei Li _{1,

2,

4} , Shao-Kun Chen _{1,

2} , Li-Yu Tang _{1,

2} , Nan Wang _{1,

2} , Xi Yang _{2,

4} , Mo-Jun Lin _{1,

2}

Affiliation

Abnormally activated vascular smooth muscle cells are key factors in pulmonary artery remodelling (PAR) and pulmonary artery hypertension (PAH). Keratin 1 is involved in inflammatory diseases; however, its role in PAH is unknown. We speculated that keratin 1 could regulate PASMCs and prevent PAH.

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