This study used whole-genome sequencing to analyze the first case of NDM-1-producing Acinetobacter baumannii belonging to the novel sequence type 1465/CC216 recovered in Brazil. The study identified an unusual plasmid carrying bla_NDM-1 gene, in which some genes of the Tn125 transposon were lost. Besides, on the chromosome, the strain reported here presented bla_OXA-106 gene, a variant of bla_OXA-51 gene, and bla_ADC-25 with ISAba1 upstream. The isolation of new STs of A. baumannii carrying bla_NDM-1 genes elicits our concerns about the possible spread of these genes among clinically relevant bacteria.

中文翻译：

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新型 ST1465/CC216 耐碳青霉烯鲍曼不动杆菌的院内谱系，含有携带 blaNDM-1 基因的异常质粒

本研究使用全基因组测序分析了巴西发现的首例产 NDM-1鲍曼不动杆菌，属于新型序列 1465/CC216。该研究发现了一种携带bla _NDM-1基因的不寻常质粒，其中 Tn 125转座子的一些基因丢失了。此外，在染色体上，这里报道的菌株呈现bla _OXA-106基因，bla _OXA-51基因的变体，以及带有IS Aba1上游的bla _ADC-25。携带bla _NDM-1的鲍曼不动杆菌新STs的分离 基因引起我们对这些基因可能在临床相关细菌中传播的担忧。