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Selective gene loss of visual and olfactory guanylyl cyclase genes following the two rounds of vertebrate specific whole genome duplications.
Genome Biology and Evolution ( IF 3.3 ) Pub Date : 2020-09-11 , DOI: 10.1093/gbe/evaa192 Matthias Gesemann 1 , Stephan C F Neuhauss 1
Genome Biology and Evolution ( IF 3.3 ) Pub Date : 2020-09-11 , DOI: 10.1093/gbe/evaa192 Matthias Gesemann 1 , Stephan C F Neuhauss 1
Affiliation
Photoreceptors convey visual information and come in two flavours; dim-light and bright-light dedicated rod and cones. Both cell types feature highly specialized phototransduction cascades that convert photonic energy into intracellular signals. While a substantial amount of phototransduction gene ohnologs are expressed either in rods or cones, visual guanylyl cyclases (GCs) involved in the calcium (Ca2+) dependent feedback regulation of phototransduction are neither rod nor cone specific. The co-existence of visual GCs in both photoreceptor types suggests that specialization of these ohnologs occurred despite their overlapping expression.
中文翻译:
在两轮脊椎动物特异性全基因组复制后,视觉和嗅觉鸟苷酸环化酶基因的选择性基因丢失。
光感受器传达视觉信息,有两种口味;暗光和亮光专用杆和锥体。两种细胞类型都具有高度专业化的光转导级联,可将光子能量转化为细胞内信号。虽然大量的光转导基因同源物在视杆细胞或视锥细胞中表达,但参与光转导的钙 (Ca 2+ ) 依赖性反馈调节的视觉鸟苷酸环化酶 (GC)既不是视杆细胞也不是视锥细胞特异性。两种光感受器类型中视觉 GC 的共存表明,尽管它们的表达重叠,但这些 ohnologs 还是发生了特化。
更新日期:2020-09-12
中文翻译:
在两轮脊椎动物特异性全基因组复制后,视觉和嗅觉鸟苷酸环化酶基因的选择性基因丢失。
光感受器传达视觉信息,有两种口味;暗光和亮光专用杆和锥体。两种细胞类型都具有高度专业化的光转导级联,可将光子能量转化为细胞内信号。虽然大量的光转导基因同源物在视杆细胞或视锥细胞中表达,但参与光转导的钙 (Ca 2+ ) 依赖性反馈调节的视觉鸟苷酸环化酶 (GC)既不是视杆细胞也不是视锥细胞特异性。两种光感受器类型中视觉 GC 的共存表明,尽管它们的表达重叠,但这些 ohnologs 还是发生了特化。