Curcumin exhibits anti‐inflammatory and antioxidant activities. We investigated the protective effects of curcumin in a renal injury rat model under dry‐heat conditions. We divided Sprague‐Dawley rats into four groups: dry‐heat 0‐ (normal temperature control group), 50‐, 100‐, and 150‐minute groups. Each group was divided into five subgroups (n = 10): normal saline (NS), sodium carboxymethylcellulose (CMCNa), and curcumin pretreated low, medium, and high‐dose (50, 100, and 200 mg/kg, respectively) groups. Compared to the normal temperature group, serum creatinine, blood urea nitrogen, urinary kidney injury molecule‐1, and neutrophil gelatinase‐associated load changes in lipoprotein (NGAL) levels were significantly increased in the dry‐heat environment group (P < .05); inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) expression and malondialdehyde (MDA) and related inflammatory factor levels were increased in the kidney tissue. Superoxide dismutase (SOD) and catalase (CAT) levels were decreased. However, following all curcumin pretreatment, the serum levels of kidney injury indicators and NGAL were decreased in the urine compared to those in the NS and CMCNa groups (P < .05), whereas renal SOD and CAT activities were increased and MDA was decreased (P < .05). Renal tissues of the 150‐minute group showed obvious pathological changes. Compared to the NS group, pathological changes in the renal tissues of the 100‐ and 200‐mg/kg curcumin groups were significantly reduced. Furthermore, iNOS and COX‐2 expression and inflammatory factor levels were decreased after curcumin treatment. Curcumin exerted renoprotective effects that were likely mediated by its antioxidant and anti‐inflammatory effects in a dry‐heat environment rat model.

中文翻译：

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姜黄素通过减少大鼠模型的氧化应激和炎症减轻干热环境下的急性肾脏损伤。

姜黄素具有抗炎和抗氧化作用。我们研究了姜黄素在干热条件下对肾损伤大鼠模型的保护作用。我们将Sprague-Dawley大鼠分为四组：干热0-（正常温度控制组），50-，100-和150分钟组。每组分为五个亚组（n = 10）：生理盐水（NS），羧甲基纤维素钠（CMCNa）和姜黄素预处理的低，中和高剂量（分别为50、100和200 mg / kg）组。与正常温度组相比，干热环境组的血清肌酐，血液尿素氮，尿肾损伤分子-1和中性粒细胞明胶酶相关的脂蛋白（NGAL）水平负荷变化显着增加（P <.05）; 肾脏组织中诱导型一氧化氮合酶（iNOS）和环氧合酶-2（COX-2）的表达以及丙二醛（MDA）和相关的炎症因子水平增加。超氧化物歧化酶（SOD）和过氧化氢酶（CAT）含量降低。然而，在所有姜黄素预处理后，与NS和CMCNa组相比，尿液中的肾损伤指标和NGAL血清水平降低（P  <.05），而肾脏SOD和CAT活性升高而MDA降低（P <.05）。150分钟组的肾脏组织显示出明显的病理变化。与NS组相比，姜黄素100mg / kg和200mg / kg组的肾脏组织病理学改变明显减少。此外，姜黄素治疗后iNOS和COX-2表达和炎性因子水平降低。在干热环境大鼠模型中，姜黄素发挥了肾脏保护作用，可能是由其抗氧化和抗炎作用介导的。