The skin is the main barrier between the human body and the outside world, which not only plays the role of a physical barrier but also functions as the first line of defence of immunology. Langerhans cells (LCs), as dendritic cells (DC) that play an important role in the immune system, are mainly distributed in the epidermis. This review focuses on the role of these epidermal LCs in regulating skin threats (such as microorganisms, ultraviolet radiation and allergens), especially psoriasis. Since human and mouse skin DC subsets share common ontogenetic characteristics, we can further explore the role of LCs in psoriatic inflammation.

中文翻译：

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朗格汉斯细胞在表皮稳态和牛皮癣发病机理中的作用。

皮肤是人体与外界之间的主要屏障，它不仅起到物理屏障的作用，而且还充当免疫学的第一道防线。朗格汉斯细胞（LC）作为树突状细胞（DC）在免疫系统中起重要作用，主要分布在表皮中。这篇综述着重于这些表皮LC在调节皮肤威胁（例如微生物，紫外线和过敏原），尤其是牛皮癣中的作用。由于人和小鼠皮肤的DC子集具有共同的本体遗传学特征，因此我们可以进一步探讨LC在银屑病炎症中的作用。