Abstract This work demonstrated a smart route of biomass-derived glucose conversion in a biphasic aqueous deep eutectic solvent (DES), which was formed by glucose, ChCl, water, and co-solvent EtAc. Four kinds of value-added furan chemicals, including 5-Hydroxymethylfurfural (HMF), 5-(Acetyloxy) methyl furfural (AMF), 5-Chloromethylfurfural (CMF) and 5-Ethoxymethylfurfural (EMF) were successfully synthesized through a single-step reaction by monitoring the reaction conditions. High yield to 73.2% furan products, including 52.9% of HMF and 17.5% of AMF was obtained from a high concentration of glucose under mild conditions. Moreover, the produced furan mixture could further be converted into other useful chemicals, 2,5-furan dicarboxylic acid (FDCA) and 2,5-dimethyl furan (DMF), directly through simple oxidation and hydrogenation methods, respectively. This study suggested a sustainable synthetic pathway from abundant biomass glucose to furan products and value-added chemicals in the presence of completely green material and catalysts, which showed advantages for the industrial application.

中文翻译：

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在水性低共熔溶剂中有效选择性地将葡萄糖转化为呋喃化学品

摘要 这项工作展示了一种在双相水性深共熔溶剂 (DES) 中进行生物质衍生葡萄糖转化的智能途径，DES 由葡萄糖、ChCl、水和共溶剂 EtAc 形成。通过一步反应成功合成了5-羟甲基糠醛（HMF）、5-（乙酰氧基）甲基糠醛（AMF）、5-氯甲基糠醛（CMF）和5-乙氧基甲基糠醛（EMF）四种高附加值的呋喃化学品通过监测反应条件。在温和条件下从高浓度的葡萄糖中获得了高产率的 73.2% 呋喃产品，包括 52.9% 的 HMF 和 17.5% 的 AMF。此外，产生的呋喃混合物可以进一步通过简单的氧化和氢化方法直接转化为其他有用的化学品，2,5-呋喃二甲酸（FDCA）和2,5-二甲基呋喃（DMF），分别。该研究提出了在完全绿色材料和催化剂存在下，从丰富的生物质葡萄糖到呋喃产品和增值化学品的可持续合成途径，显示出工业应用的优势。