The patho-etiology of mental disorders with onset in childhood or adolescence other than autism spectrum disorder and attention-deficit/hyperactivity disorder remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases. Quality of MAs was measured with AMSTAR-2. Out of 6,851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8,884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium and antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. Quality of meta-analyses was rated as high in two, moderate in one, low in four, critically low in two, and not pertinent in one (individual participant data). Methodologically-sound research is needed in this field.

除自闭症谱系障碍和注意力缺陷/多动障碍外，儿童或青少年期发病的精神障碍的病因病因仍是未知的。我们对与儿童期/青春期发作的精神障碍相关的环境因素进行了荟萃分析（MAs）的综述。我们搜索了Pubmed-MEDLINE / EMBASE / PsycInfo数据库。MAs的质量使用AMSTAR-2进行测量。在6,851篇初始参考文献中，有10篇符合入选标准，提供了12种潜在环境因素与9种疾病之间的23种关联（案例：8884； N = 3,660,670）。尽管近半数的协会名义上具有重要意义，但它们都不符合令人信服或具有高度暗示性的证据。提示性证据（母亲暴露于锂和具有神经运动缺陷的抗精神病药）支持单一关联，但受指征混杂影响。另外十个协会的证据薄弱，而十二个协会的统计意义不明显。荟萃分析的质量被评为高，二，中，一，低，四，临界低，二，与一项不相关（个人数据）。在这个领域需要方法论上合理的研究。