Nanoparticle-enabled strategies to combat antimicrobial-resistant (AMR) bacteria are highly demanded, which hopefully can overcome the barriers associated with conventional antibiotics to achieve high therapeutic efficacy by improving pharmacokinetics. Here, we report the controlled fabrication of multiple Ag nanoparticles (AgNPs) containing ZIF-8 derived hollow -Zn-O-Si- nanospheres with mesoporous wall, Ag&Zn@mesSiO₂, which can release and recapture Ag⁺ ions, thus, efficiently eradicate planktonic methicillin-resistant Staphylococcus aureus (MRSA) in vivo. The AgNPs encapsulated inside the large internal cavities of the hollow structure can kill MRSA at significantly reduced dosages due to the synergistic effect of released Zn and Ag ions, which was 10 times lower in comparison with single Ag⁺ application. The boomerang-like release-and-recapture scheme of the Ag⁺ ions helps to greatly reduce the notorious Ag toxicity. Such novel structured nanocomposites with widened Ag therapeutic window possess great potential as nanoantibiotic for tackling MRSA infection.

迫切需要纳米技术来对抗抗菌素耐药性（AMR）细菌，这有望克服传统抗生素相关的障碍，从而通过改善药代动力学来实现高疗效。在这里，我们报告了多个含ZIF-8衍生的中空-Zn-O-Si-纳米球和中孔壁Ag＆Zn @ mesSiO ₂的多个Ag纳米粒子（AgNPs）的受控制备，该纳米球可以释放和捕获Ag ⁺离子，从而有效消除耐浮游耐甲氧西林金黄色葡萄球菌（MRSA）体内。由于释放的锌和银离子的协同作用，封装在中空结构大内腔内部的AgNP可以以显着降低的剂量杀死MRSA，这与单次应用Ag ⁺相比要低10倍。Ag ⁺离子的类似飞旋镖的释放和捕获方案有助于大大降低臭名昭著的Ag毒性。这种具有宽广的Ag治疗窗口的新型结构的纳米复合材料作为纳米抗生素具有巨大的潜力来解决MRSA感染。