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MCU meets cardiolipin: Calcium and disease follow form.
Cell Calcium ( IF 4 ) Pub Date : 2020-09-12 , DOI: 10.1016/j.ceca.2020.102287 Priscilla See-Wai Yeung 1 , Murali Prakriya 1
中文翻译:
MCU符合心磷脂:钙和疾病遵循形式。
更新日期:2020-09-12
Cell Calcium ( IF 4 ) Pub Date : 2020-09-12 , DOI: 10.1016/j.ceca.2020.102287 Priscilla See-Wai Yeung 1 , Murali Prakriya 1
Affiliation
Cardiolipin (CL) is a cone-shaped lipid found nearly exclusively in the inner mitochondrial membrane of animal cells. Disruption of CL synthesis leads to abnormalities in mitochondrial shape and function, but the underlying causes are incompletely understood. We highlight a new study that reveals that the activity of the mitochondrial calcium uniporter (MCU) is regulated by CL, advancing our understanding of the mechanisms of CL-linked human disease.
中文翻译:
MCU符合心磷脂:钙和疾病遵循形式。
心磷脂(CL)是一种锥形脂质,几乎只存在于动物细胞的线粒体内膜中。CL合成中断导致线粒体形状和功能异常,但根本原因尚不完全清楚。我们重点介绍了一项新研究,该研究揭示了线粒体钙单向转运蛋白(MCU)的活性受CL的调节,从而加深了我们对与CL相关的人类疾病机理的理解。