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Mitochondria membrane transformations in colon and prostate cancer and their biological implications.
Biochimica et Biophysica Acta (BBA) - Biomembranes ( IF 3.4 ) Pub Date : 2020-09-12 , DOI: 10.1016/j.bbamem.2020.183471
Shani Ben Zichri 1 , Sofiya Kolusheva 2 , Alexander I Shames 3 , Elina Abaev Schneiderman 4 , Juan L Poggio 5 , David E Stein 5 , Elena Doubijensky 2 , Dan Levy 4 , Zulfiya Orynbayeva 5 , Raz Jelinek 6
Affiliation  

Mitochondria have emerged as important determinants in cancer progression and malignancy. However, the role of mitochondrial membranes in cancer onset and progression has not been thoroughly investigated. This study compares the structural and functional properties of mitochondrial membranes in prostate and colon cancer cells in comparison to normal mitochondria, and possible therapeutic implications of these membrane changes. Specifically, isolation of cell mitochondria and preparation of inverted sub-mitochondrial particles (SMPs) illuminated significant cancer-induced modulations of membrane lipid compositions, fluidity, and activity of cytochrome c oxidase, one of the key mitochondrial enzymes. The experimental data further show that cancer-associated membrane transformations may account for mitochondria targeting by betulinic acid and resveratrol, known anti-cancer molecules. Overall, this study probes the relationship between cancer and mitochondrial membrane transformations, underlying a potential therapeutic significance for mitochondrial membrane targeting in cancer.



中文翻译:

结肠和前列腺癌中的线粒体膜转化及其生物学意义。

线粒体已成为癌症进展和恶性肿瘤的重要决定因素。然而,线粒体膜在癌症发作和进展中的作用尚未得到彻底研究。这项研究比较了与正常线粒体相比,前列腺癌和结肠癌细胞中线粒体膜的结构和功能特性,以及这些膜改变的潜在治疗意义。具体来说,细胞线粒体的分离和反向线粒体亚颗粒(SMPs)的制备阐明了癌症诱导的膜脂质成分,流动性和细胞色素c活性的显着调节。氧化酶,一种关键的线粒体酶。实验数据进一步表明,与癌症相关的膜转化可能是由白蛋白和白藜芦醇(已知的抗癌分子)靶向线粒体的原因。总体而言,这项研究探讨了癌症与线粒体膜转化之间的关系,潜在地针对针对癌症的线粒体膜靶向治疗具有潜在的治疗意义。

更新日期:2020-09-22
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