当前位置: X-MOL 学术Biochem. Biophys. Res. Commun. › 论文详情
Potent antiviral effect of silver nanoparticles on SARS-CoV-2.
Biochemical and Biophysical Research Communications ( IF 2.985 ) Pub Date : 2020-09-11 , DOI: 10.1016/j.bbrc.2020.09.018
Sundararaj S Jeremiah,Kei Miyakawa,Takeshi Morita,Yutaro Yamaoka,Akihide Ryo

The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. We evaluated a plethora of AgNPs of different sizes and concentration and observed that particles of diameter around 10 nm were effective in inhibiting extracellular SARS-CoV-2 at concentrations ranging between 1 and 10 ppm while cytotoxic effect was observed at concentrations of 20 ppm and above. Luciferase-based pseudovirus entry assay revealed that AgNPs potently inhibited viral entry step via disrupting viral integrity. These results indicate that AgNPs are highly potent microbicides against SARS-CoV-2 but should be used with caution due to their cytotoxic effects and their potential to derange environmental ecosystems when improperly disposed.



中文翻译:

银纳米颗粒对SARS-CoV-2的有效抗病毒作用。

由于缺乏有效的抗病毒措施,COVID-19的大流行没有得到控制。银纳米颗粒(AgNP)已被研究具有抗病毒特性,并被认为具有抑制SARS-CoV-2的作用。由于需要有效的抗SARS-CoV-2药物,我们评估了AgNPs的抗病毒作用。我们评估了许多不同大小和浓度的AgNPs,观察到直径约10 nm的颗粒在浓度范围为1至10 ppm时可有效抑制细胞外SARS-CoV-2,而在浓度为20 ppm或更高时观察到细胞毒性作用。基于萤光素酶的假病毒进入试验表明,AgNPs通过破坏病毒完整性来有效抑制病毒进入步骤。

更新日期:2020-10-17
全部期刊列表>>
微生物研究
亚洲大洋洲地球科学
NPJ欢迎投稿
自然科研论文编辑
ERIS期刊投稿
欢迎阅读创刊号
自然职场,为您触达千万科研人才
spring&清华大学出版社
城市可持续发展前沿研究专辑
Springer 纳米技术权威期刊征稿
全球视野覆盖
施普林格·自然新
chemistry
物理学研究前沿热点精选期刊推荐
自然职位线上招聘会
欢迎报名注册2020量子在线大会
化学领域亟待解决的问题
材料学研究精选新
GIANT
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
阿拉丁试剂right
上海中医药大学
浙江大学
西湖大学
化学所
北京大学
清华
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
清华大学-1
武汉大学
浙江大学
天合科研
x-mol收录
试剂库存
down
wechat
bug