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Development of pore functionally graded Ti6Al4V scaffolds with biocompatible surface for bone repair
Transactions of the IMF ( IF 1.9 ) Pub Date : 2019-08-27 , DOI: 10.1080/00202967.2019.1644768 E. Shahimoridi 1 , S. M. Kalantari 1 , A. Molaei 2
Transactions of the IMF ( IF 1.9 ) Pub Date : 2019-08-27 , DOI: 10.1080/00202967.2019.1644768 E. Shahimoridi 1 , S. M. Kalantari 1 , A. Molaei 2
Affiliation
ABSTRACT Pore functionally graded scaffolds (PFGS) were successfully produced via the powder metallurgical space holder technique as a result of the evaporation of magnesium (Mg) particles. The arranged layers containing 20, 40, and 60 vol.% Mg particles were compacted and sintered. In addition, morphological and porosimetry studies were performed to determine an optimum structure. PFGSs were characterised for homogeneous distribution and low agglomeration of micro- and macro-pores. Optimum PFGSs contained 5–60% porosity with an average macro-pore size of about 100 µm. Finally, an hydroxyapatite (HA) nanoparticles coating (about 10 µm thickness) was uniformly deposited on PFGS by the sol–gel technique and analysed. PFGSs studied exhibited greatly improved biocompatibility, cyto-compatibility and cell attachment. HA coating augmented the cell proliferation rate of PFGS from 70% to 87% after 14 days incubation.
中文翻译:
具有生物相容性表面的用于骨修复的孔功能梯度 Ti6Al4V 支架的开发
摘要 由于镁 (Mg) 颗粒的蒸发,通过粉末冶金空间支架技术成功地生产了孔功能梯度支架 (PFGS)。将含有 20、40 和 60 vol.% Mg 颗粒的排列层压实并烧结。此外,还进行了形态学和孔隙率研究以确定最佳结构。PFGS 具有均匀分布和微孔和大孔低聚集的特点。最佳 PFGS 含有 5-60% 的孔隙率,平均大孔径约为 100 µm。最后,通过溶胶-凝胶技术将羟基磷灰石 (HA) 纳米颗粒涂层(约 10 µm 厚)均匀沉积在 PFGS 上并进行分析。研究的 PFGS 表现出大大提高的生物相容性、细胞相容性和细胞附着性。
更新日期:2019-08-27
中文翻译:
具有生物相容性表面的用于骨修复的孔功能梯度 Ti6Al4V 支架的开发
摘要 由于镁 (Mg) 颗粒的蒸发,通过粉末冶金空间支架技术成功地生产了孔功能梯度支架 (PFGS)。将含有 20、40 和 60 vol.% Mg 颗粒的排列层压实并烧结。此外,还进行了形态学和孔隙率研究以确定最佳结构。PFGS 具有均匀分布和微孔和大孔低聚集的特点。最佳 PFGS 含有 5-60% 的孔隙率,平均大孔径约为 100 µm。最后,通过溶胶-凝胶技术将羟基磷灰石 (HA) 纳米颗粒涂层(约 10 µm 厚)均匀沉积在 PFGS 上并进行分析。研究的 PFGS 表现出大大提高的生物相容性、细胞相容性和细胞附着性。