ABSTRACT Percutaneous ethanol injection of hepatocellular carcinoma is indicated for the treatment of small tumours superimposed on liver cirrhosis. It involves destroying the cancer cells of the liver by injecting ethanol using a needle placed in the centre of the tumour under ultrasound or computed tomography scanner. A precise pre-operative planning of such intervention is a major challenge for a successful intervention. It requires an accurate estimation of the injected dose and the three-dimensional tumour centre location. In this work, we propose a computer-assisted pre-operative planning based on a three-dimensional reconstruction of all involved anatomical structures in order to avoid damaging surrounding healthy tissues, dangerous probe trajectories and under-treatment of the tumour. This system consists of two main modules : A decision support module that helps physicians to make a percutaneous treatment decision and a therapeutic support one that deals with needle guidance planning once percutaneous treatment is chosen. The proposed system was evaluated on two clinical data sets and has led to promising results.

中文翻译：

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肝细胞癌经皮乙醇注射的计算机辅助规划

摘要 肝细胞癌经皮乙醇注射适用于治疗叠加在肝硬化上的小肿瘤。它涉及通过在超声或计算机断层扫描仪下使用放置在肿瘤中心的针头注射乙醇来破坏肝脏的癌细胞。这种干预的精确术前计划是成功干预的主要挑战。它需要准确估计注射剂量和三维肿瘤中心位置。在这项工作中，我们提出了一种基于所有相关解剖结构的三维重建的计算机辅助术前计划，以避免损坏周围的健康组织、危险的探针轨迹和对肿瘤的治疗不足。该系统由两个主要模块组成：一个帮助医生做出经皮治疗决定的决策支持模块和一个在选择经皮治疗后处理针头引导计划的治疗支持模块。所提出的系统在两个临床数据集上进行了评估，并产生了有希望的结果。