Abstract

A series of novel 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones was synthesized by reacting methyl thienyl-2-carbonylpyruvate with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activity of the synthesized compounds was studied.

中文翻译：

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5-（己）芳基-3-羟基-1-羟乙基-4-（噻吩基-2-羰基）-3-吡咯啉-2-酮的合成及抑菌活性

摘要

通过使噻吩基-2-羰基丙酮酸甲酯与甲醇的混合物反应，合成了一系列新颖的5-（杂）芳基-3-羟基-1-羟基乙基-4-（噻吩基-2-羰基）-3-吡咯啉-2-酮。二恶烷中的芳族或杂环醛和乙醇胺。研究了合成化合物的抗菌和抗真菌活性。