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Anxiolytic Activity of 11H-2,3,4,5-Tetrahydro[1,3]Diazepino[1,2-a]Benzimidazole and 2-Mercaptobenzimizadole Derivatives
Russian Journal of Bioorganic Chemistry ( IF 1 ) Pub Date : 2020-01-01 , DOI: 10.1134/s1068162020010124
A. A. Spasov , O. N. Zhukovskaya , D. V. Maltsev , M. V. Miroshnikov , M. O. Skripka , K. T. Sultanova , A. S. Morkovnik

This paper presents a study of the anxiolytic activity of compounds that belong to two classes of chemical groups: derivatives of 11H-2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole (BIF) and derivatives of 2-mercaptobenzimidazole (AZH). The study has revealed that the studied compounds exhibit different degrees of tranquilizing action. The most potent anxiolytics were compounds BIF-66 and AZH-57. These compounds hold promise for an in-depth study of their neuropsychotropic profile.

中文翻译:

11H-2,3,4,5-四氢[1,3]二氮杂[1,2-a]苯并咪唑和2-巯基苯并咪唑衍生物的抗焦虑活性

本文介绍了属于两类化学组的化合物的抗焦虑活性研究:11H-2,3,4,5-四氢[1,3]二氮杂[1,2-a]苯并咪唑 (BIF) 的衍生物和 2-巯基苯并咪唑 (AZH) 的衍生物。研究表明,所研究的化合物表现出不同程度的镇静作用。最有效的抗焦虑药是化合物 BIF-66 和 AZH-57。这些化合物有望对其神经精神特征进行深入研究。
更新日期:2020-01-01
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