Abstract

A device for optical biopsy with a fluorescence spectroscopy channel and a fine-needle optical probe for use in fine-needle aspiration biopsy of liver tumors is described. To test the developed device, experimental measurements of the fluorescence of internal organs of a laboratory rat were carried out in vivo while exposing the tissue surface to mitochondrial uncoupling to induce changes in cell respiration. The results of the model experiment showed the ability of the developed channel to detect changes in fluorescence due to changes in the processes of oxidative phosphorylation of mitochondria.

中文翻译：

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测试细针光学探针以记录细胞呼吸辅酶的荧光变化

摘要

描述了具有荧光光谱通道的光学活检装置和用于肝肿瘤的细针穿刺活检的细针光学探针。为了测试开发的设备，在体内对组织大鼠的内部器官的荧光进行了实验测量，同时将组织表面暴露于线粒体解偶联以诱导细胞呼吸变化。模型实验的结果表明，开发的通道能够检测由于线粒体的氧化磷酸化过程的变化而导致的荧光变化。