Abstract

A novel, efficient, and green catalytic system under visible light irradiation has been introduced for the synthesis of anticancer biarylquinolooxazocino-quinoxaline-1-ones in one-pot sequence. The developed synthetic approach will be successfully utilized for the synthesis of various bioactive biarylquinolone in near future. Also, the cytotoxicity profile of these scaffolds has unveiled their superb cytoselectivity in HeLa and MCF-7 cell line compared to cisplatin.

Graphic abstract

中文翻译：

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一锅顺序在可见光下联合钯/曙红Y催化抗癌联芳基喹啉恶恶恶唑烷喹喔啉-1-酮的直接合成：重新验证的概念证明

摘要

一种新型，高效，绿色的可见光辐射催化体系已被引入以一锅法的顺序合成抗癌联芳基喹喔啉恶喹啉喹喔啉-1-酮。所开发的合成方法将在不久的将来成功用于各种生物活性联芳基喹诺酮的合成。而且，与顺铂相比，这些支架的细胞毒性特征揭示了它们在HeLa和MCF-7细胞系中具有极好的细胞选择性。

图形摘要