The study focuses on the fabrication and properties evaluation of dual functional electrospun polycaprolactone scaffolds incorporating antibiotic drug cefuroxime and having custom tailored topography for the support of human cells to be used in tissue regeneration. The scaffolds were evaluated in regard to their morphology, total porosity, thermal properties, tensile properties and cells adhesion/growth, thus to define the effect of both drug content and physical architecture on the scaffolds properties. Both the addition of the drug and the scaffolds custom topography resulted in higher total porosity (up to 90%), while the fibers diameter highest reduction was up to 73%. The type of 3 D printed collector influenced scaffolds tensile properties, thus the increase of the tensile strength was due to the change of the central cylinder height in the hexagonal geometry of the collectors. Cells distribution and spreading on the electrospun scaffolds after 72 hours, showed that scaffolds with custom topography have more evenly scattered cells than the ones with random electrospun fibers. The study has demonstrated that both drug concentration and scaffolds target topography influenced the scaffolds properties and both can be optimized depending on scaffolds demands.

这项研究的重点是结合了抗生素头孢呋辛并具有定制的拓扑结构以支持人类细胞用于组织再生的双功能电纺聚己内酯支架的制备和性能评估。对支架的形态，总孔隙率，热性能，拉伸性能和细胞粘附/生长进行了评估，从而确定了药物含量和物理结构对支架性能的影响。药物的添加和支架的自定义形貌均导致较高的总孔隙率（高达90％），而纤维直径最高减少率高达73％。3D打印收集器的类型影响了支架的拉伸性能，因此，抗张强度的增加是由于集尘器六角形几何形状中中心圆柱高度的变化。72小时后，细胞在电纺支架上的分布和扩散表明，具有自定义外形的支架比具有随机电纺纤维的支架具有更均匀的分散细胞。该研究表明，药物浓度和支架的目标形态都会影响支架的性能，并且都可以根据支架的需求进行优化。