Abstract A low-cost potentiometric sensor based on a molecularly imprinted polymer was developed for the determination of matrine in herbal medicine samples. The imprinted material was synthesized by the use of matrine as template, methacrylic acid (MAA) as the monomer, ethylene glycol dimethyl acrylate (EGDMA) as the cross linker, 2,2′-azo-bisisobutyronitrile (AIBN) as the initiator, and toluene and dodecanol as the porogenic agent. The electrode sensing membrane was fabricated by incorporating the ground imprinted particles into the polyvinyl chloride substrate that was subsequently incorporated into a laboratory constructed ion-selective electrode. The prepared imprinted sensor exhibited a rapid Nernst response across the concentration range from 1 × 10−5 to 1 × 10−1 M with a detection limit equal to 9.3 × 10−6 M. The analytical capabilities support the direct determination of matrine in herbal medicine. The analytical results were verified by a standard ultraviolet absorption spectrophotometry protocol. The proposed sensor manifested a series of advantages, including high selectivity and sensitivity, enhanced stability and low cost, that provides a wide number of potential applications for herbal analysis.

中文翻译：

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基于分子印迹聚合物的低成本电位传感器，用于快速测定草药中的苦参碱

摘要 开发了一种基于分子印迹聚合物的低成本电位传感器，用于测定草药样品中的苦参碱。以苦参碱为模板，甲基丙烯酸（MAA）为单体，乙二醇丙烯酸二甲酯（EGDMA）为交联剂，2,2'-偶氮二异丁腈（AIBN）为引发剂，合成了印迹材料。甲苯和十二醇作为致孔剂。电极传感膜是通过将磨碎的印迹颗粒掺入聚氯乙烯基板中制成的，该基板随后被掺入实验室构建的离子选择性电极中。制备的印迹传感器在 1 × 10-5 到 1 × 10-1 M 的浓度范围内表现出快速的能斯特响应，检测限等于 9.3 × 10-6 M。分析能力支持直接测定草药中的苦参碱。分析结果通过标准的紫外吸收分光光度法协议进行验证。所提出的传感器表现出一系列优势，包括高选择性和灵敏度、增强的稳定性和低成本，为草药分析提供了广泛的潜在应用。