当前位置: X-MOL 学术Fluid Dyn. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Investigation of the Influence of Smooth Muscle Contractions on the Properties of the Wall of a Small Arterial Vessel
Fluid Dynamics ( IF 0.9 ) Pub Date : 2020-03-01 , DOI: 10.1134/s001546282002010x
N. Kh. Shadrina

Abstract— The plane problem of the effect of contractions of smooth muscle cells in the wall of a resistance vessel under the action of transmural pressure on the radius and the distribution of stresses in the vascular wall is considered. It is assumed that in the inactivated state the vessel wall is hyperelastic, and the contraction of smooth muscle cells as a result of activation contributes to the circumferential stress alone. Based on the model and published experimental data, a functional dependence of the active stress on the concentration of the activator of smooth muscle contraction is obtained. Calculations show that the total stress in the wall is determined mainly by the active component. With increasing pressure, contractions of smooth muscle cells lead to decrease in stresses, while the pattern of the distribution of circumferential stresses changes. The circumferential stretch ratios also decrease with activation and their distribution becomes more homogeneous. In both passive and active vessels, the modulus of the ratio of the radial to circumferential stress decreases with increase in tension, this ratio being several times greater in the active vessel than in the passive one.

中文翻译:

平滑肌收缩对小动脉血管壁特性影响的研究

摘 要:研究了血管壁在透壁压力作用下阻力血管壁平滑肌细胞收缩效应的平面问题和血管壁应力分布问题。假定在失活状态下,血管壁是超弹性的,并且作为激活结果的平滑肌细胞的收缩仅对周向应力有贡献。基于模型和已发表的实验数据,获得了主动应力对平滑肌收缩激活剂浓度的函数依赖性。计算表明,壁中的总应力主要由活性成分决定。随着压力的增加,平滑肌细胞的收缩导致压力降低,而周向应力的分布模式发生了变化。圆周拉伸比也随着活化而降低,并且它们的分布变得更加均匀。在被动和主动血管中,径向与周向应力之比的模量随着张力的增加而降低,主动血管中的这一比率比被动血管大几倍。
更新日期:2020-03-01
down
wechat
bug