Solubilization of poorly water–soluble bioactive molecules in neutral aqueous media is a challenge in the development of functional foods and pharmaceuticals. Kodama et al. fabricated renatured β‐1,3‐1,6‐glucan (r‐glucan) nanoparticles (NPs) by neutralization of alkali‐denatured β‐1,3‐1,6‐glucan then centrifugation. Inclusion complexes were subsequently prepared by simply mixing host and guest solutions. Given the ease of preparation and sustained release of the guest molecules, the r‐glucan NPs have potential as a carrier scaffold for various applications. The schematic illustrates r‐glucan incorporating various bioactive molecules in the distorted helical cavities, where the molecules are stacked and twisted along the helical structure of β‐1,3‐1,6‐glucan. (DOI: 10.1002/bip.23349)

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在中性水性介质中增溶水溶性差的生物活性分子是功能食品和药物开发中的一个挑战。Kodama等。通过中和碱变性的β-1,3-1,6-葡聚糖，然后离心来制造复性的β-1,3-1,6-葡聚糖（r-葡聚糖）纳米颗粒（NPs）。随后通过简单地混合宿主溶液和客体溶液来制备包合物。考虑到易于制备和持续释放客体分子，r-葡聚糖NPs具有作为多种应用的载体支架的潜力。该示意图说明了在扭曲的螺旋形腔体中掺入了各种生物活性分子的r-葡聚糖，这些分子沿β-1,3-1,6-葡聚糖的螺旋结构堆叠并扭曲。（DOI：10.1002 / bip.23349）