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High fluorescence LaOBr/coumarin organic–inorganic composite nanomaterials for ultra-sensitive Fe3+ sensing, fluorescence imaging and water-based ink anti-counterfeiting applications
Journal of Materials Chemistry C ( IF 6.4 ) Pub Date : 2020-09-11 , DOI: 10.1039/d0tc03354e
Liheng Sun 1, 2, 3, 4, 5 , Jingshi Liu 1, 2, 3, 4, 5 , Shihan Xu 6, 7, 8, 9 , Biao Dong 1, 2, 3, 4, 5 , Jiekai Lv 1, 2, 3, 4, 5 , Songtao Hu 1, 2, 3, 4, 5 , Bingshuai Zhou 1, 2, 3, 4, 5 , Bo Shen 1, 2, 3, 4, 5 , Yuqi Wang 1, 2, 3, 4, 5 , Lin Xu 1, 2, 3, 4, 5 , Wen Xu 1, 2, 3, 4, 5 , Xue Bai 1, 2, 3, 4, 5 , Hongwei Song 1, 2, 3, 4, 5
Affiliation  

The detection of metal ions such as Fe3+ ions at the cellular level is of vital importance for monitoring life activities and disease diagnosis. Coumarin-based molecules are uniquely selective fluorescence probes for detecting Fe3+ ions; however, due to their lower water solubility, applying them in biological detection is a bottleneck problem. Herein, a centrally hydrophobic/externally hydrophilic strategy is proposed and a novel coumarin-based fluorescence probe was successfully synthesized by using LaOBr via a nucleophilic substitution reaction. The hydrophobic part of each coumarin molecule faces inward, and the hydrophilic part (iron-ion-capturing group) faces outward, allowing each coumarin molecule to be fully stretched. Compared with the coumarin-based N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-7-hydroxycoumarin-3-carboxamide (DAT) solution, the water solubility of the LaOBr/DAT composite solution was greatly improved, with enhanced fluorescent properties and detection performance. In a water solvent, the detection limit of the composite considerably improved from 300 nM to 440 pM, and the composite demonstrated better stability and selectivity for detecting Fe3+. The composite probe was applied in Fe3+ detection at the cellular level and in invisible anti-counterfeiting. This material design is of universal significance for improving the performance of other organic molecules.

中文翻译:

高荧光LaOBr /香豆素有机-无机复合纳米材料,用于超灵敏的Fe3 +感测,荧光成像和水性油墨防伪应用

在细胞水平上检测金属离子(例如Fe 3+离子)对于监测生命活动和疾病诊断至关重要。基于香豆素的分子是用于检测Fe 3+离子的独特选择性荧光探针。然而,由于它们的水溶性较低,将它们应用于生物检测是一个瓶颈问题。在此,在中央的疏水/亲水性外部策略提出和新型香豆素系荧光探针成功地通过使用合成LaOBr经由亲核取代反应。每个香豆素分子的疏水部分都向内,而亲水部分(铁离子捕获基团)则朝外,从而使每个香豆素分子都可以被完全拉伸。与基于香豆素的N- [2-羟基-1,1-双(羟甲基)乙基] -7-羟基香豆素-3-羧酰胺(DAT)溶液相比,LaOBr / DAT复合溶液的水溶性大大提高,具有增强的荧光特性和检测性能。在水溶剂中,该复合物的检出限从300 nM显着提高到440 pM,并且该复合物表现出更好的稳定性和选择性,可检测出Fe 3+。复合探针应用于Fe 3+在细胞级别和隐形防伪中进行检测。这种材料设计对于提高其他有机分子的性能具有普遍意义。
更新日期:2020-10-16
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