Dynamic covalent polymers are materials formed by reversible covalent bonds and non-covalent interactions through an adaptive constitutional dynamic chemistry. The implementation of dynamic covalent polymers in gene delivery has recently emerged due to their responsive and adaptive features. Indeed, such an approach offers the alluring promise of discovering optimal delivery vectors self-fitted to their nucleic acid cargos and responsive to environmental changes (e.g. pH changes or the presence of a biomolecular target). This review will discuss more precisely the structural features of the molecular building blocks used so far, the architecture of the resulting dynamic covalent polymers from linear to 2D and 3D, and the covalent and supramolecular self-assembly processes at play in nucleic acid recognition and delivery, showcasing in particular the very few examples of adaptive self-assembly of dynamic covalent polymers templated by nucleic acids and responsive to the presence of biomolecular targets found in cell membranes that facilitate cell entry.

中文翻译：

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用于基因转染的阳离子动态共价聚合物

动态共价聚合物是通过可适应的组成动态化学由可逆的共价键和非共价相互作用形成的材料。由于它们的响应性和适应性特征，动态共价聚合物在基因传递中的应用近来已经出现。实际上，这种方法提供了诱人的希望，即发现适合其核酸货物并响应环境变化的最佳递送载体（例如pH值变化或存在生物分子靶标）。这篇综述将更精确地讨论迄今为止使用的分子构件的结构特征，所得的动态共价聚合物从线性到2D和3D的结构以及在核酸识别和传递中发挥作用的共价和超分子自组装过程，其特别显示了由核酸模板化的动态共价聚合物的自适应自组装的极少数实例，并且对在细胞膜中发现的促进细胞进入的生物分子靶标的存在作出响应。