Polyoxometalates (POMs) are a kind of inorganic cluster metal complex with various biological activities, such as anti-Alzheimer's disease, antibacterial, anti-cancer, anti-diabetes, anti-virus, and so on. The mechanism of their action at the molecular level is basically unknown. However, some studies have shown that the inhibitory effect of POMs on several enzyme families (such as α-glucosidase, tyrosinase, protein kinase or exonuclease) may be related to the pharmacological properties of POMs. In addition, POMs also inhibited sialyltransferase, thiotransferase, deacetylase and virus reverse enzyme to different degrees. Combining the results of research groups, it was found the structure and composition of POMs may indirectly affect their inhibition ability. Therefore, this paper reviews the inhibitory effects of POMs on various enzymes in order to contribute to the application of polyoxometalates in biomedicine.

中文翻译：

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多金属氧酸盐抑制酶的研究进展

多金属氧酸盐（POMs）是一种具有多种生物活性的无机簇状金属配合物，例如抗阿尔茨海默氏病，抗菌，抗癌，抗糖尿病，抗病毒等。它们在分子水平上的作用机理基本上是未知的。但是，一些研究表明，POM对几种酶家族（如α-葡萄糖苷酶，酪氨酸酶，蛋白激酶或核酸外切酶）的抑制作用可能与POM的药理特性有关。另外，POMs也不同程度地抑制了唾液酸转移酶，硫转移酶，脱乙酰酶和病毒逆转酶。结合研究小组的研究结果，发现POM的结构和组成可能间接影响其抑制能力。因此，