Background: Free radicals are the main cause of numerous diseases. Their overproduction needs to be controlled in order to combat several ailments. The current study deals with the discovery of new free radical scavengers.

Methods: Substituted N-hydrazinecarbothioamide indazoles 1-18 were evaluated for DPPH and ABTS radical scavenging activities.

Results and Discussions: All synthetic compounds possess good radical DPPH and ABTS scavenging potential in the ranges of IC50 = 2.11 ± 0.17 - 5.3 ± 0.11 μM and IC50 = 2.31 ± 0.06 - 5.5 ± 0.07 μM, respectively, as compared to standard ascorbic acid having IC50 = 2.02 ± 0.11 μM for DPPH and IC50 = 2.1 ± 0.07 μM for ABTS.

Conclusion: These compounds could serve as leads for antioxidant activity that have the ability to control free radical generation and ward off free radical-induced disorders.

中文翻译：

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发现新的N-肼基甲硫酰胺吲哚杂化物：作为潜在的自由基（ABTS和DPPH）清除剂

背景：自由基是多种疾病的主要原因。为了应对多种疾病，需要控制其生产过剩。当前的研究涉及发现新的自由基清除剂。

方法：评估了取代的N-肼基甲硫酰胺吲唑1-18的DPPH和ABTS自由基清除活性。

结果与讨论：与具有抗坏血酸的标准抗坏血酸相比，所有合成化合物在IC50 = 2.11±0.17-5.3±0.11μM和IC50 = 2.31±0.06-5.5±0.07μM范围内均具有良好的自由基DPPH和ABTS清除能力。 DPPH的IC50 = 2.02±0.11μM，ABTS的IC50 = 2.1±0.07μM。

结论：这些化合物可作为抗氧化活性的先导，具有控制自由基产生和抵御自由基引起的疾病的能力。