The genomic diversity of the domestic dog is an invaluable resource for advancing understanding of mammalian biology, evolutionary biology, morphologic variation, and behavior. There are approximately 350 recognized breeds in the world today, many established through hybridization and selection followed by intense breeding programs aimed at retaining or enhancing specific traits. As a result, many breeds suffer from an excess of particular diseases, one of many factors leading to the recent trend of “designer breed” development, i.e. crossing purebred dogs from existing breeds in the hope that offspring will be enriched for desired traits and characteristics of the parental breeds. We used a dense panel of 150,106 SNPs to analyze the population structure of the Australian labradoodle (ALBD), to understand how such breeds are developed. Haplotype and admixture analyses show that breeds other than the poodle (POOD) and Labrador retriever (LAB) contributed to ALBD formation, but that the breed is, at the genetic level, predominantly POOD, with all small and large varieties contributing to its construction. Allele frequency analysis reveals that the breed is enhanced for variants associated with a poodle-like coat, which is perceived by breeders to have an association with hypoallergenicity. We observed little enhancement for LAB-specific alleles. This study provides a blueprint for understanding how dog breeds are formed, highlighting the limited scope of desired traits in defining new breeds.

家犬的基因组多样性是增进对哺乳动物生物学，进化生物学，形态变异和行为的了解的宝贵资源。当今世界上大约有350个公认的品种，其中许多是通过杂交和选择建立的，随后是旨在保持或增强特定性状的密集育种计划。结果，许多犬种都患有特殊疾病，这是导致“设计犬”发展的最新趋势的众多因素之一，即与现有犬种杂交纯种狗，以期为后代提供丰富的所需性状和特征。育种。我们使用了150,106个SNP的密集面板来分析澳大利亚拉布拉多犬（ALBD）的种群结构，以了解此类犬种是如何发育的。单倍型和混合分析表明，除了贵宾犬（POOD）和拉布拉多犬（LAB）以外的其他品种都促进了ALBD的形成，但在遗传水平上，该品种主要是POOD，所有大小型的品种都对其构成有贡献。等位基因频率分析显示，与贵宾犬样外套相关的变体增强了该品种，饲养员认为这与低变应原性有关。我们观察到LAB特定等位基因几乎没有增强。这项研究为理解犬种的形成提供了一个蓝图，突出了在定义新品种时所需性状的有限范围。所有小型和大型品种都为其建造做出了贡献。等位基因频率分析显示，与贵宾犬样外套相关的变体提高了该品种的繁殖力，饲养员认为这与低变应原性有关。我们观察到LAB特定等位基因几乎没有增强。这项研究为了解狗的品种形成提供了一个蓝图，突出了在定义新品种时所需性状的有限范围。所有小型和大型品种都为其建造做出了贡献。等位基因频率分析显示，与贵宾犬样外套相关的变体增强了该品种，饲养员认为这与低变应原性有关。我们观察到LAB特定等位基因几乎没有增强。这项研究为了解狗的品种形成提供了一个蓝图，突出了在定义新品种时所需性状的有限范围。