Abstract

Occurrence of putative invasive pulmonary aspergillosis was screened in 153 consecutive adult intensive care unit (ICU) patients with respiratory samples addressed for mycological diagnosis during a 6-week period at the emergence of coronavirus disease 2019 (COVID-19) pandemic. Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) was observed for 106 patients (69.3%). Nineteen of them (17.9%) with positive Aspergillus results were considered as having putative invasive pulmonary aspergillosis. These observations underline the risk of pulmonary aspergillosis in COVID-19 patients, even in patients not previously known to be immunosuppressed, advocating active search for Aspergillus infection and prompt antifungal treatment. Standardized surveillance protocols and updated definitions for ICU putative invasive pulmonary aspergillosis are needed.

Lay Abstract

Adult ICU patients with respiratory samples addressed for mycological diagnosis were screened during the emergence of COVID-19 pandemic. Positive SARS-CoV-2 PCR was observed for 106 patients, nineteen of them (17.9%) having aspergillosis. This underlines the risk of aspergillosis in COVID-19 patients.

中文翻译：

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2019年冠状病毒病（COVID-19）的重症患者的肺曲霉病。

摘要

在2019年冠状病毒病（COVID-19）大流行出现的6周内，对连续153名成人重症监护病房（ICU）患者进行呼吸道标本进行真菌学诊断的筛查，确定是否存在侵袭性肺曲霉病。观察到106例患者（69.3％）发生了严重的严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）聚合酶链反应（PCR）。其中有19例（17.9％）的曲霉菌阳性结果被认为具有推定的浸润性肺曲霉病。这些观察结果突显了COVID-19患者甚至在以前不曾被免疫抑制的患者中发生肺曲霉病的风险，主张积极寻找曲霉菌感染并及时进行抗真菌治疗。需要ICU假定的侵袭性肺曲霉病的标准化监测方案和更新定义。

放置摘要

在COVID-19大流行期间，对患有ICU且有呼吸道标本进行真菌学诊断的成年患者进行了筛查。观察到106例患者的SARS-CoV-2 PCR阳性，其中十九例（17.9％）患有曲霉病。这强调了COVID-19患者曲霉病的风险。