Background 

The prevalence and prognostic implications of acute cardiac injury (ACI), as a complication of coronavirus disease 2019 (COVID-19), remain unclear.

Objectives 

We conducted a systematic review and meta-analysis to investigate the relationship between ACI and mortality risk in COVID-19 patients.

Methods 

Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in abstracting data and assessing validity. We searched MEDLINE, Scopus and Web of Science to locate all articles published up to 10 April 2020 reporting data of COVID-19 survivors and nonsurvivors developing ACI as a complication of the infection. Quality assessment was performed using the Newcastle–Ottawa quality assessment scale. Data were pooled using the Mantel–Haenszel random effects models with odds ratio as the effect measure with the related 95% confidence interval. Statistical heterogeneity between groups was measured using the Higgins I² statistic.

Results 

Eight studies, enrolling 1686 patients (mean age 59.5 years), met the inclusion criteria and were included in the final analysis. Data regarding the outcome of patients complicated with ACI were available for 1615 patients. Of these, 387 (23.9%) experienced ACIs as COVID-19 complications during the hospitalization. The incidence of ACI was significantly higher among non survivors when compared with survivors (61.6 vs. 6.7%, P < 0.0001). The pooled analysis confirmed a significantly increased risk of death in COVID-19 patients complicated with ACI during the disease (odds ratio: 21.6, 95% confidence interval: 8.6–54.4, P < 0.0001, I² = 82%).

Conclusion 

Development of ACI during COVID-19 significantly increases the risk of death during the infection.

中文翻译：

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2019年冠状病毒病并发急性心脏损伤的发病率和死亡率风险：系统评价和荟萃分析

背景 

作为2019年冠状病毒病（COVID-19）的并发症，急性心脏损伤（ACI）的患病率和预后影响尚不清楚。

目标 

我们进行了系统的审查和荟萃分析，以调查ACI和COVID-19患者死亡风险之间的关系。

方法 

在提取数据和评估有效性时遵循了系统评价和荟萃分析指南的首选报告项目。我们搜索了MEDLINE，Scopus和Web of Science，以查找截至2020年4月10日发表的所有报道COVID-19幸存者和非幸存者发展ACI作为感染并发症的数据的所有文章。使用纽卡斯尔-渥太华质量评估量表进行质量评估。使用Mantel–Haenszel随机效应模型合并数据，并以比值比作为具有相关95％置信区间的效应度量。组之间的统计异质性使用希金斯I ²统计量度。

结果 

八项研究招募了1686例患者（平均年龄59.5岁），符合纳入标准，被纳入最终分析。1615名患者可获得有关并发ACI的患者预后的数据。其中，387例（23.9％）在住院期间经历了ACI作为COVID-19并发症的经历。与幸存者相比，非幸存者的ACI发生率显着更高（61.6比6.7％，P <0.0001）。汇总分析证实，在疾病期间COVID-19并发ACI的患者死亡风险显着增加（赔率：21.6，95％置信区间：8.6-54.4，P <0.0001，I ² = 82％）。

结论 

在COVID-19期间发生ACI会显着增加感染期间死亡的风险。