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The relationship between fluid biomarkers and clinical outcomes in sports-related concussions: a systematic review.
Brain Injury ( IF 1.9 ) Pub Date : 2020-09-10 , DOI: 10.1080/02699052.2020.1802780
Jessica Meyer 1 , Christopher Bartolomei 2 , Adam Sauer 2 , Martha Sajatovic 1, 3 , Christopher M Bailey 1, 4
Affiliation  

Objectives

The literature on fluid biomarkers for concussion has primarily focused on comparing athletes with and without a diagnosis of concussion and on examining the relationship between fluid biomarkers and exposure to head trauma. This systematic literature review aims to examine the strength of evidence for fluid biomarkers to be associated with clinically relevant outcomes in sports-related concussion.

Methods

A systematic literature review was conducted using EmBASE, PubMed, and CINAHL. English-language articles that included athletes participating in organized sports and reported the relationship between at least one fluid biomarker and at least one clinical outcome measure, or provided data that could be used to analyze this relationship, were included.

Results

Studies of the relationship between fluid biomarkers and clinical outcomes of concussion have yielded small or variable effects. There were significant inconsistencies in methodology including duration of time post-injury of biomarker collection, use of control groups, the number of time points post-injury that biomarkers were collected, and what clinical outcomes were utilized.

Conclusion

There is currently insufficient evidence to support a relationship between any of the included fluid biomarkers and clinical outcome measures of concussion. Future research including clinical outcome measures and using standardized study design and methodology is necessary.



中文翻译:

运动相关脑震荡中液体生物标志物与临床结果之间的关系:系统评价。

目标

关于脑震荡的液体生物标志物的文献主要侧重于比较有或没有脑震荡诊断的运动员,并研究流体生物标志物与头部外伤之间的关系。这项系统的文献综述旨在检查与运动相关脑震荡的临床相关结果相关的液体生物标志物的证据强度。

方法

使用EmBASE,PubMed和CINAHL进行了系统的文献综述。英文文章包括运动员参加有组织的运动并报告了至少一种液体生物标志物和至少一种临床结果指标之间的关系,或者提供了可用于分析这种关系的数据。

结果

对液体生物标志物与脑震荡临床结局之间关系的研究产生了很小的影响或影响很大。方法学上存在重大不一致之处,包括生物标志物收集后损伤的持续时间,对照组的使用,生物标志物收集后损伤时间点的数量以及利用了哪些临床结果。

结论

当前没有足够的证据支持所包含的任何液体生物标志物与脑震荡的临床结果指标之间的关系。未来的研究包括临床结果测量以及使用标准化研究设计和方法是必要的。

更新日期:2020-09-23
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