In the last two decades, quantitative NMR (qNMR) has become increasingly important for the analysis of pharmaceuticals, chemicals, and natural products including dietary supplements. For the purpose of quality control and chemical standardization of a large variety of pharmaceutical, chemical, and medicinal products, qNMR has proven to be a valuable orthogonal quantification method and a compelling alternative to chromatographic techniques. This work reviews a fundamental component of the early development of qNMR, reflected in the pioneering work of the late George M. Hanna during the years between 1984 and 2006 at the U.S. Food and Drug Administration (FDA). Because Hanna performed the majority of his groundbreaking work on a 90 MHz instrument, his legacy output connects to recent progress in low-field benchtop NMR instrumentation. Hanna gradually established the utility of qNMR for the routine quality control analyses practiced in pharmaceutical and related operations well ahead of his peers. His work has the potential to inspire new developments in qNMR applied to small molecules of biomedical importance.

中文翻译：

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用于药物分析的定量 NMR (qNMR)：美国 FDA 的 George Hanna 的开创性工作

在过去的二十年中，定量 NMR (qNMR) 在分析药物、化学品和天然产品（包括膳食补充剂）方面变得越来越重要。为了对大量药品、化学制品和医药产品进行质量控制和化学标准化，qNMR 已被证明是一种有价值的正交定量方法，并且是色谱技术的一种引人注目的替代方法。这项工作回顾了 qNMR 早期发展的一个基本组成部分，反映在已故 George M. Hanna 在 1984 年至 2006 年期间在美国食品和药物管理局 (FDA) 的开创性工作中。由于 Hanna 在 90 MHz 仪器上完成了他的大部分开创性工作，因此他的传统输出与低场台式 NMR 仪器的最新进展相联系。Hanna 逐步确立了 qNMR 在制药和相关操作中的常规质量控制分析方面的实用性，远远领先于他的同行。他的工作有可能激发 qNMR 应用于具有生物医学重要性的小分子的新发展。