Ferroptosis is a metabolic disorder of lipid oxides in cells, which leads to abnormal metabolism under the catalysis of iron, which produces an expansive number of lipids, wrecks the redox in cells, attacks biological macromolecules and triggers cell death. This death process was marked by the increase of cytoplasmic and lipid reactive oxygen species, the decrease of mitochondria and the higher density of mitochondrial membrane. Non‐coding RNA (ncRNA) is a kind of small RNA molecules found in recent years, which can transcribe but do not encode proteins and have specific functions. These ncRNAs play a key role in controlling gene expression by combining with proteins or other molecules to turn genes on or off. Ferroptosis is viewed as a leap forward in the medication of tumors and some intractable maladies. Under the circumstances that there are still many mysteries in the study of ferroptosis, the research on the role of ncRNAs in ferroptosis is even less. By consulting the pertinent literature, this article reviews the research advance about ncRNAs on ferroptosis, which provides a new research direction and ideas for the study of ferroptosis.

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ncRNA 调控铁死亡：一个新方向

铁死亡是细胞内脂质氧化物的代谢紊乱，在铁的催化下导致代谢异常，产生大量脂质，破坏细胞内的氧化还原，攻击生物大分子，引发细胞死亡。这种死亡过程的特点是细胞质和脂质活性氧增加、线粒体减少和线粒体膜密度增加。非编码RNA（ncRNA）是近年来发现的一类小分子RNA，可以转录但不编码蛋白质，具有特定的功能。这些 ncRNA 通过与蛋白质或其他分子结合来打开或关闭基因，在控制基因表达方面发挥着关键作用。铁死亡被视为治疗肿瘤和一些顽固疾病的一次飞跃。在铁死亡研究还存在诸多谜团的情况下，关于ncRNA在铁死亡中的作用的研究更是少之又少。本文通过查阅相关文献综述了ncRNAs对铁死亡的研究进展，为铁死亡的研究提供了新的研究方向和思路。