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Baicalein inhibits FURIN‐MT1‐MMP‐mediated invasion of ectopic endometrial stromal cells in endometriosis possibly by reducing the secretion of TGFB1
American Journal of Reproductive Immunology ( IF 3.6 ) Pub Date : 2020-09-10 , DOI: 10.1111/aji.13344
Jun-Ya Ke 1, 2, 3 , Jing Yang 1, 2, 3 , Jing Li 1, 4 , Zhen Xu 1, 4 , Ming-Qing Li 1, 2, 3 , Zhi-Ling Zhu 1, 4
Affiliation  

Endometriosis (EMs) is characterized by the presence of endometrial stroma and glands outside the uterus. Our previous study showed that baicalein inhibited proliferation and induced apoptosis in EMs. However, the effects of baicalein on the invasiveness of ectopic endometrial stromal cells (EcESCs) remain unclear. The aim of this study was to assess the potential anti‐invasive effect of baicalein and determine the underlying mechanism.

中文翻译:

黄芩素可能通过减少 TGFB1 的分泌来抑制 FURIN-MT1-MMP 介导的子宫内膜异位症中异位子宫内膜基质细胞的侵袭

子宫内膜异位症 (EMs) 的特征在于子宫外存在子宫内膜间质和腺体。我们之前的研究表明,黄芩素可抑制 EM 的增殖并诱导其凋亡。然而,黄芩素对异位子宫内膜基质细胞 (EcESCs) 侵袭性的影响仍不清楚。本研究的目的是评估黄芩素的潜在抗侵袭作用并确定其潜在机制。
更新日期:2020-09-10
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