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Large ovarian endometriomas are associated with high pre-operative anti-Müllerian hormone concentrations
Reproductive BioMedicine Online ( IF 4 ) Pub Date : 2020-09-11 , DOI: 10.1016/j.rbmo.2020.09.008
Horace Roman 1 , Isabella Chanavaz-Lacheray 2 , Oana Mircea 3 , Benoit Berby 4 , Lise Dehan 4 , Sophia Braund 4 , Eric Verspyck 4 , Lucian Puscasiu 3
Affiliation  

Research question

Are large ovarian endometriomas associated with high pre-operative anti-Müllerian hormone (AMH) concentrations?

Design

Data from 332 women who underwent AMH measurement before surgery for endometriosis were prospectively recorded in a large database. Univariate analysis compared AMH concentrations in terms of the patients’ baseline characteristics. A multivariate model was used to identify variables having an independent relationship with AMH concentration.

Results

Among 332 women included in the study, 47.6% were aged 18–30 years, 67.8% were infertile and 85.5% were nulliparous. A total of 66.3% had ovarian endometriomas, and 10.8% had cysts measuring over 6 cm. Bilateral cysts over 3 cm were recorded in 24.7% of the women. Univariate analysis identified two variables that had a statistically significant relationship with AMH concentration: the woman's age (P = 0.01) and cyst size (P < 0.001). Multivariate analysis revealed that ages of 36–40 years and over 40 years showed a significant association with lower AMH concentrations (P = 0.02 and P = 0.009, respectively), while a cyst size of over 6 cm was statistically associated with high AMH concentrations (P < 0.001), after adjustment for smoking, parity, rectosigmoid endometriotic nodules and a bilateral location of endometriomas.

Conclusions

Pre-operative AMH concentration was significantly increased in women with large endometriomas of over 6 cm, independent of their age or the presence of bilateral endometriomas. This is relevant for both surgeons and patients when planning surgery in women with an intention to conceive post-operatively.



中文翻译:

大卵巢子宫内膜异位症与术前抗苗勒管激素浓度高有关

研究问题

大型卵巢子宫内膜异位症与术前抗苗勒管激素 (AMH) 浓度高有关吗?

设计

来自 332 名在子宫内膜异位症手术前接受 AMH 测量的女性的数据被前瞻性地记录在一个大型数据库中。单变量分析根据患者的基线特征比较了 AMH 浓度。多变量模型用于识别与 AMH 浓度具有独立关系的变量。

结果

在纳入研究的 332 名女性中,47.6% 的年龄在 18-30 岁之间,67.8% 的女性不育,85.5% 的女性未生育。共有 66.3% 患有卵巢子宫内膜异位症,10.8% 患有超过 6 cm 的囊肿。在 24.7% 的女性中记录到超过 3 cm 的双侧囊肿。单变量分析确定了两个与 AMH 浓度具有统计学显着关系的变量:女性的年龄 ( P  = 0.01) 和囊肿大小 ( P  < 0.001)。多变量分析显示,36-40 岁和 40 岁以上的年龄与较低的 AMH 浓度显着相关(分别为P  = 0.02 和P  = 0.009),而超过 6 cm 的囊肿大小与高 AMH 浓度在统计学上相关( < 0.001),在调整吸烟、产次、直肠乙状结肠子宫内膜异位结节和双侧子宫内膜异位瘤位置后。

结论

术前 AMH 浓度在超过 6 cm 的大子宫内膜异位瘤的女性中显着增加,与她们的年龄或双侧子宫内膜异位瘤的存在无关。这对于计划对打算在术后受孕的女性进行手术时的外科医生和患者都是相关的。

更新日期:2020-09-11
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