Fe(III) loaded porous silica nanoparticles have great value for establishing anticancer drug delivery system. In this study, host-metal-guest carrier named as MM–SN–NH₂-Fe was obtained by grafting aminopropyl and Fe(III) onto macro-mesoporous silica nanoparticles (MM-SN). Doxorubicin hydrochloride (DOX) has been chosen as a model anticancer drug and the NH₂–Fe-DOX coordination bond structure has been constructed on the pore surface using the iron necessary for the organism. The release performance of DOX loaded MM–SN–NH₂-Fe showed higher pH response release by cleavage of the Fe-DOX bond or the NH₂–Fe coordination bond. Cytotoxicity assay indicated that DOX loaded MM–SN–NH₂-Fe presented stronger anti-cancer activity against MCF-7 and MCF-7/ADR cells compared to that of free DOX and DOX loaded MM-SN. In vivo, DOX based nanoparticles significantly prolonged systemic circulation and DOX loaded MM–SN–NH₂-Fe presented the best antitumor effect. As expected, we developed a novel carrier with pH-triggered release and high anti-cancer activity for DOX delivery system, which has great value in anticancer treatment.

Fe（III）负载的多孔二氧化硅纳米粒子对建立抗癌药物传递系统具有重要价值。在这项研究中，通过将氨基丙基和Fe（III）接枝到大介孔二氧化硅纳米粒子（MM-SN）上，获得了名为MM-SN-NH ₂ -Fe的主体金属客体载体。盐酸阿霉素（DOX）已被选作典型的抗癌药物，并且使用生物体所需的铁在孔表面构建了NH ₂ -Fe-DOX配位键结构。负载了DOX的MM–SN–NH ₂ -Fe的释放性能表明，通过裂解Fe-DOX键或NH ₂ -Fe配位键，pH响应释放更高。细胞毒性试验表明DOX负载MM–SN–NH ₂与自由的DOX和装载DOX的MM-SN相比，-Fe具有更强的针对MCF-7和MCF-7 / ADR细胞的抗癌活性。在体内，基于DOX的纳米颗粒可显着延长全身循环，而DOX负载的MM–SN–NH ₂ -Fe具有最佳的抗肿瘤作用。不出所料，我们为DOX输送系统开发了一种具有pH触发释放和高抗癌活性的新型载体，在抗癌治疗中具有重要价值。