当前位置: X-MOL 学术Biomaterials › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Harnessing the bioresponsive adhesion of immuno-bioglue for enhanced local immune checkpoint blockade therapy.
Biomaterials ( IF 14.0 ) Pub Date : 2020-09-11 , DOI: 10.1016/j.biomaterials.2020.120380
Kye Il Joo 1 , Yeonsu Jeong 1 , Sung-Min Hwang 2 , Mincheol Shin 1 , Jaeyun Lee 1 , Garima Sharma 3 , Haena Lee 2 , Sin-Hyeog Im 4 , Hyung Joon Cha 1
Affiliation  

Despite the great promise of immune checkpoint blockade (ICB) therapy for cancer treatment, the currently available options for ICB treatment pose major clinical challenges, including the risk of severe systemic autoimmune responses. Here, we developed a novel localized delivery platform, immuno-bioglue (imuGlue), which is inspired by the intrinsic underwater adhesion properties of marine mussels and can allow the optimal retention of anti-PD-L1 drugs at tumor sites and the on-demand release of drugs in response to the tumor microenvironment. Using a triple-negative breast cancer and melanoma models, we found that imuGlue could significantly enhance anti-tumor efficacy by eliciting a robust T cell-mediated immune response while reducing systemic toxicity by preventing the rapid diffusion of anti-PD-L1 drugs into the systemic circulation and other tissues. It was also demonstrated that imuGlue could be successfully utilized for combination therapy with other immunomodulatory drugs to enhance the anti-tumor efficacy of ICB-based immunotherapy, demonstrating its versatility as a new treatment option for cancer immunotherapy.



中文翻译:

利用免疫生物胶的生物反应性粘附力来增强局部免疫检查点封锁疗法。

尽管免疫检查点封锁(ICB)治疗癌症的前景广阔,但目前可用的ICB治疗选择带来了重大的临床挑战,包括发生严重的全身自身免疫反应的风险。在这里,我们开发了一种新型的局部递送平台免疫生物胶(imuGlue),该平台受海洋贻贝固有的水下粘附特性的启发,可以使抗PD-L1药物在肿瘤部位和按需最佳保留响应于肿瘤微环境释放药物。使用三阴性乳腺癌和黑色素瘤模型,我们发现imuGlue可以通过引发强大的T细胞介导的免疫反应来显着增强抗肿瘤功效,同时通过阻止抗PD-L1药物迅速扩散进入全身循环和其他组织来降低全身毒性。还证明了imuGlue可以成功地与其他免疫调节药物联合使用,以增强基于ICB的免疫疗法的抗肿瘤功效,证明其多功能性是癌症免疫疗法的新治疗选择。

更新日期:2020-09-15
down
wechat
bug