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Follow-up of liver transplant recipients
Best Practice & Research Clinical Gastroenterology ( IF 3.2 ) Pub Date : 2020-09-11 , DOI: 10.1016/j.bpg.2020.101682
James Neuberger 1
Affiliation  

The number of surviving liver allograft recipients is increasing almost exponentially. The quality and length of life is increasing but most recipients have reduced survival and quality of life compared with healthy matched individuals.

Causes of premature death include cardio and cerebrovascular disease, renal failure, graft failure, de novo malignancy and recurrent disease.

Follow-up is needed lifelong to ensure graft and patient health and ensure that complications are recognised and treated early. Immunosuppression is kept to the appropriate minimum and prophylactic interventions are given early, such as use of statins and tight control of blood pressure and blood sugar.

Recipients will require life-long follow-up, and this is placing an increasing burden on transplant units. Follow-up is best done by close collaboration between the Liver Transplant Unit, the local hospital and primary care team. Involvement of other health care practitioners, such as recipient coordinators, pharmacists, dermatologists and addiction specialists may improve outcomes.

Key to successful follow-up are agreed protocols and good communication between the recipients and all relevant health care providers.

Use of IT allows for better communication and will support use of video and telephone consultations in selected instances.

The most appropriate follow-up will depend on many factors, including logistic and geographic issues, local experience.

The provision of well-funded and supported registries at local, national and international levels will allow for improvements in management.



中文翻译:

肝移植受者的随访

存活的同种异体肝移植受者的数量几乎呈指数增长。生活质量和寿命都在增加,但与健康的匹配个体相比,大多数接受者的生存率和生活质量都降低了。

过早死亡的原因包括心脑血管疾病、肾衰竭、移植物衰竭、新发恶性肿瘤和疾病复发。

需要终生随访,以确保移植物和患者的健康,并确保及早识别和治疗并发症。将免疫抑制保持在适当的最低限度,并尽早进行预防性干预,例如使用他汀类药物以及严格控制血压和血糖。

接受者将需要终生随访,这给移植单位带来了越来越大的负担。后续行动最好由肝脏移植科、当地医院和初级保健团队密切合作来完成。其他医疗保健从业者的参与,例如接受者协调员、药剂师、皮肤科医生和成瘾专家,可能会改善结果。

成功跟进的关键是接受者和所有相关医疗保健提供者之间商定的协议和良好的沟通。

使用 IT 可以实现更好的沟通,并支持在特定情况下使用视频和电话咨询。

最合适的后续行动将取决于许多因素,包括后勤和地理问题、当地经验。

在地方、国家和国际各级提供资金充足和支持的登记处将有助于改进管理。

更新日期:2020-11-04
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